Endocrine Abstracts

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

Introduction: Chronic kidney disease (CKD) is one of the leading causes ofdisability and mortality in patients with diabetes mellitus. Existence of specific phenotypes of diabetic kidney disease (DKD) is established nowadays. The prevalence of the classic albuminuric phenotype has decreased by 24% over the past decade (NHANES).The purpose of our work was to investigate the phenotypic features of DKD depending on the type of diabetes.<p class="abstext...

Introduction: Diabetes mellitus is known as a factor of cognitive impairment. The risk of dementia in patients with type 2 diabetes mellitus (T2DM) increases almost twice. The results of epidemiological, visualization and autopsy studies showed the presence of both cerebrovascular and neurodegenerative mechanisms of brain lesions. Cell death of key substrates – neurons and endothelial cells lays in the basis of the formation of cerebral disorders. Granzyme B (GrB) is a s...

Introduction: In order to improve the early diagnostics of cholelithiasis in patients with chronic acalculous cholecystitis combined with diabetes mellitus type 2 (DM), individual parameters are usually not sufficient. Therefore, we decided to establish and analyze the correlation between the serum and biochemical parameters of bile to evaluate biochemical connections in a system of lipid homeostasis by comorbid pathology. The aim of our study was to determine the peculiaritie...

Introduction: Thyroid hormones affect sex hormone metabolism and reproductive function in women. Infertility in women with autoimmune thyroiditis is more difficult to treat than in women with normal thyroid function. On the other hand, immune factors are dependent on exogenous and endogenous factors, interrelated with hormones and are important regulators of fertility, autoimmune reactionsand can lead to infertility and increase the risk of pregnancy complications and miscarri...

Introduction: The prevalence of manifest hypothyroidism by various data is 0.2–2%, sub-clinical – up to 3% in men and up to 10% in women, and in people over 70 years old – 13–14%. The presence of concomitant gastrointestinal diseases significantly limits the possibility of hypothyroidism compensation; these patients need higher doses of levothyroxine. According to a number of researchers, hypothyroidism is often accompanied by small intestinal bacterial...

Background: Vitamin D deficiency is a major public health problem in Ukraine. The aim of this cross-sectional study was to study the status of Vitamin D and parathyroid hormone (PTH) level in women of reproductive age in Carpathian region.Materials and methods: A cross-sectional study was carried on a total of 416 nonpregnant and nonlactating women in the reproductive age group of 19–45 years during summer 2018. Demographic, socioeconomic class, an...

Background: Vitamin D deficiency is widespread in Ukraine, particularly among older adults. Factors associated with vitamin D deficiency are not well defined.The aim of the study was to evaluate vitamin D status and its correlatation among older adults of 5 communities in Ukrainian Carpathians.Materials and methods: This cross–sectional study was based on study data for 1254 men and women aged 20–82 years. Anthropometri...

IntroductionThe problem of ecologically caused iodine deficiency is acute in many countries around the world, including Ukraine, where the endemic zone for the development of iodine deficiency is Northern Bukovina. The possible participation of iodine in the induction or manifestation of autoimmune processes in the thyroid gland and their role in reproduction is discussed. Iodine deficiency is significantly higher in infertile women than in women with no...

It is well known that the range of disorders of various organs and systems in thyroid dysfunction is diverse, due to the scale of the impact of thyroid hormones on the body. One of the most characteristic clinical manifestations of thyrotoxicosis is changes in the gastrointestinal tract in the form of dysbiosis. Some studies have found inconsistencies in the association of these filotypes with the presence of thyrotoxicosis. In addition, there is no data in the literature on t...